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Cardiac markers refer to a class of proteins or enzymes that are released into the blood when the heart muscle is damaged. The detection of blood levels of myocardial markers can be used to diagnose the time limit of myocardial infarction, identify the degree of myocardial damage, and evaluate the prognosis of patients.
BNP (B-type natriuretic peptide, brain natriuretic peptide,) is secreted and synthesized by ventricular cells. Following transcription and translation of the BNP gene, the initial gene product is produced, which is a 134 amino acid pre-BNP precursor (pre-proBNP). The amino acid signal peptide of pre-proBNP was immediately removed, resulting in proBNP of 108 amino acids. Next, proBNP is broken down in blood by proteolytic enzymes into two parts: a biologically inactive, amino-terminal part containing 76 amino acids (NT-proBNP) and a biologically active 32 amino acid BNP.
| Cat.No. | Product Name | Application-Platform | Product Description |
|---|---|---|---|
| HA102-5M | NT-proBNP Antibody | Detection-FIA/CLIA | Mouse Antibody, a.a.r. 27-31 |
| HA102-6S | NT-proBNP Antibody | Capture-FIA/CLIA | Sheep Antibody, a.a.r. 42-46 |
| HP102-3 | NT-proBNP Antigen | Quality Control-FIA/CLIA | E.coli |
BNP is a biologically active protein with a half-life of 20 minutes and a stability time of only 1 hour in vitro, and its level is easily influenced by the drug of choice. It is difficult for clinicians to determine whether elevated BNP levels are the result of drug therapy or cardiac dysfunction. The inactive NT-proBNP has a half-life of 60-120 minutes and is stable in vitro for up to 24 hours. It has higher sensitivity and is not affected by rh-BNP, making it easier for clinicians to accurately detect early and mild heart failure.
| Cat.No. | Product Name | Application-Platform | Product Description |
|---|---|---|---|
| HA102-9M | BNP Antibody | Detection-FIA | Mouse Antibody |
| HA102-10M | BNP Antibody | Capture-FIA | Mouse Antibody |
| HA102-9M | BNP Antibody | Detection-CLIA | Mouse Antibody |
| HA102-17S | BNP Antibody | Capture-CLIA | Sheep Antibody |
ST2 is called growth stimulating expression gene 2 in English and soluble growth stimulating expression gene 2 in Chinese, and is located on chromosome 2 2q11.2. ST2 contains 328 amino acids with 3 immunoglobulin domains and 9 glycosylation sites. ST2 can be expressed in the heart, lung, kidney and small intestine, as well as in lymphocytes, mast cells and various endothelial cells.
| Cat.No. | Product Name | Application-Platform | Product Description |
|---|---|---|---|
| HA139-1H | ST-2 Antibody | Detection-CLIA | Humanized Antibody, Mouse Antibody |
| HA139-2M | ST-2 Antibody | Capture-CLIA | Mouse Antibody |
| HP139-1 | ST2 Antigen | Quality Control-FIA/CLIA | CHO |
Homocysteine (HCY) is a sulfur-containing amino acid that is produced in the body during the metabolism of methionine, an essential amino acid derived from dietary protein. It is an intermediate in the methionine cycle and can be converted into cysteine via the transsulfuration pathway or back into methionine via remethylation.
| Cat.No. | Product Name | Application-Platform | Product Description |
|---|---|---|---|
| HA230-1M | HCY Antibody | Detection/Capture-FIA/CLIA | Mouse Antibody, specific to S-Adenosylhomocysteine |
| HA230-2M | HCY Antibody | Detection-FIA | Mouse Antibody, specific to S-Adenosylhomocysteine |
| HA230-3M | HCY Antibody | Detection-FIA | Mouse Antibody, specific to S-Adenosylhomocysteine |
| HP230-1 | SAH-BSA | Capture-FIA | / |
