Clinical Significance

Creatine kinase isoenzymes (CKMB) are one of the isoenzymes of creatine kinase (CK), mainly distributed in cardiomyocytes. CK-MB increases at 4-6 hours after myocardial injury, peaks at 24 hours, and returns to normal within 3 days. It is one of the most widely used clinical markers of myocardial injury today. It is an enzymatic component that has four isoenzyme forms: muscle, brain, hybrid and mitochondrial. Muscle type (MM), brain type (BB), hybrid type (MB) and mitochondrial type (MiMi).
Creatine kinase isoenzyme is of great significance in clinical diagnosis. When various diseases including muscle atrophy and myocardial infarction occur, the level of creatine kinase in human serum increases rapidly. It is considered that the determination of creatine in the diagnosis of myocardial infarction Kinase activity is more reliable than doing an electrocardiogram. In myocardial infarction, creatine kinase increases within 6 hours of onset, peaks within 24 hours, and returns to normal within 3-4 days. Among them, the isoenzyme CK-MB of creatine kinase has the highest diagnostic specificity. Creatine kinase has attracted extensive attention and in-depth research because of its important physiological function and clinical application value.

Product Information