Clinical Significance

Placental growth factor (PLGF) was first isolated and purified from a human placental cDNA library in 1991 by Maglione et al. PLGF is synthesized mainly by syncytial trophoblasts and binds to tyrosinase receptors located on trophoblasts and vascular endothelial cells, and is a protein with autocrine effects on trophoblast function and paracrine effects on vascular growth. PLGF has a unique regulatory effect on trophoblast and endothelial cells, and can promote neovascularization. PLGF levels in pregnant women can be used clinically to diagnose placental insufficiency and to predict, identify and monitor the treatment of preterm pre-eclampsia.

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