Clinical Significance

T3, also known as triiodothyronine, is a tyrosine containing iodine, which is synthesized in the thyroid gland cells using iodine and tyrosine as raw materials. When the thyroid gland is subjected to TSH and thyroid hormone is released, the glandular epithelial cells first swallow the thyroglobulin in the follicular cavity into the glandular cells by swallowing, and under the action of lysosomal protein hydrolase, the thyroglobulin is broken down, and the liberated T4 and T3 can enter the blood circulation through the capillaries. The number of T4 on the thyroglobulin molecule far exceeds that of T3, so T4 accounts for about 90% of the total amount of hormone secreted, while T3 is secreted in a smaller amount, but its activity is high, five times that of T4.

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