Clinical Significance

IL-6 has a molecular weight of 26 kD and consists of 184 amino acids. IL-6 is a pleiotropic cytokine that regulates a variety of cellular functions, including cell proliferation, cell differentiation, immune defense mechanisms, and hematopoiesis.
After infection and inflammation, IL-6 was first generated and the level increased rapidly, reaching a peak at 2h, and its elevated level was consistent with the severity of infection, and induced procalcitonin (PCT) and CRP at 2h of infection, respectively. and began to increase after 6h. IL-6 is a sensitive indicator for the early diagnosis of acute infection, especially for the differential diagnosis of early neonatal sepsis, and has important reference significance for formulating treatment plans and improving prognosis of children. The increase of IL-6 was positively correlated with the severity of the disease, and the increased amplitude reflected the severity of the disease. The sustained high-level expression in critically ill patients can be used as a sensitive indicator for evaluating the severity and prognosis of patients with sepsis and MODS, and can reflect the effect of antibiotic treatment more quickly. The sensitivity of IL-6 to distinguish infection from non-infection is higher than that of PCT and CRP. It can also be used to evaluate the severity of infection and evaluate prognosis. When IL-6>1000μg/L, it warns that patients with severe infection have poor prognosis, and prompts clinicians to adjust diagnosis and treatment in time. plan. Therefore, in recent years, IL-6 as an inflammatory marker has become more and more widely used in clinical applications.

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