Clinical Significance

PGI and PGII are proteins secreted by gastric mucosal cells. About 1% of pepsinogen enters the blood and exists stably, and the secretion of pepsinogen will be changed when the stomach shrinks. Therefore, the levels of PGI and PGII in serum can be used as reliable indicators of gastric mucosal atrophy. At present, the detection of pepsinogen level has been considered as "serological gastroscopic detection". There are many studies on the clinical use of pepsinogen in Asia, and there is clear evidence that the detection of pepsinogen level can effectively detect atrophic gastritis, and it has become a consensus that atrophic gastritis is an early precancerous lesion of intestinal metaplasia and gastric cancer. A large population study showed that when PGI/PGII was increased, the sensitivity and specificity of the detection increased to 93% and 88%, respectively.

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