Clinical Significance

The human GRP gene encodes a 148-amino acid prepro-gastrin-releasing peptide protein (preproGRP). After the signal peptide is dissociated, preproGRP is converted into ProGRP1-125, and ProGRP1-125 continues to generate mature gastrin-releasing peptide GRP1-27, GRP18-27 and a C-terminal extension peptide, which continues to generate ProGRP containing 68 amino acids. The GRP produced by tumor cells of SCLC patients is positively correlated with ProGRP. Since the half-life of gastrin-releasing peptide is very short, only two minutes, it is impossible to detect in blood, so ProGRP is determined.
As a specific tumor marker for small cell lung cancer (SCLC), ProGRP can not only be used for the early diagnosis of SCLC, but also help to judge the treatment effect and early detection of tumor recurrence.

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