Clinical Significance

The fibrinolytic system in the human body plays an important role in maintaining the normal permeability of blood vessel walls, maintaining blood flow and tissue repair. In order to maintain a normal physiological state, in the case of trauma or damage to the blood vessel, a thrombus is formed in the blood vessel to prevent blood loss from the damaged blood vessel. When coagulation occurs in the body, thrombin acts on fibrin and converts it into cross-linked fibrin. At the same time, the fibrinolytic system is activated to degrade fibrin to form various fragments. The sum of uncrosslinked fibrin and crosslinked fibrin degradation products is FDP, while only crosslinked fibrin degradation produces D-dimer (D-Dimer).
Elevated levels of D-Dimer, which represent clot formation in the circulatory system, are a sensitive, but not specific, marker of acute thrombosis. The increase of D-dimer reflects the existence of important molecular markers of enhanced coagulation and fibrinolytic activity in vivo.

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