Clinical Significance

Myoglobin (Myo) is a protein that stores and distributes oxygen in mammalian cells (mainly muscle cells). It consists of a polypeptide chain and a prosthetic group heme. Apomyoglobin that removes heme is called globin, which has obvious homology in amino acid sequence with the subunits of hemoglobin (a globin chain and P-globin chain), their conformation and function Also very similar.
Determination of serum myoglobin Myoglobin can be used as the most sensitive indicator in the early diagnosis of acute myocardial infarction (AMI). However, the specificity is poor, and skeletal muscle injury, trauma, renal failure and other diseases can lead to its increase. Although Myo positive cannot diagnose AMI, it can be used as an important indicator for early diagnosis of AMI. If Myo is negative, myocardial infarction is basically excluded, and it can also be used for the diagnosis of reinfarction. Combined with clinical conditions, if Myo increases again, it should be considered as reinfarction. or infarct extension.

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