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Cardiac Troponin I (cTnI)

Clinical Significance

Cardiac troponin is composed of subunits of three distinct genes: cardiac troponin T (cTnT), cardiac troponin I (cTnI), and troponin C (TnC). Cardiac troponin exists in cardiomyocytes in the form of cTnI-CT complex and free cTnI. After myocardial injury is released into the blood circulation, cTnI-CT can be further decomposed into cTnI-C complex and free cTnI, which metabolize The product is excreted by the kidneys. Three isoforms of TnI (troponin I) exist: two skeletal muscle troponin I (sTnI) and cardiac troponin I (cTnI). There is also a 40% difference with the amino acid sequence of the skeletal muscle type.
    Due to the small molecular weight of cTnI, free cTn is rapidly released from the cardiomyocytes to the circulatory system after the onset of the disease, and the concentration in the blood increases rapidly. At the same time, due to the sequence difference between cTnI and sTnI, CK and CK-MB may increase when muscle tissue other than myocardium is injured or diseased, while cTnI will not exceed its critical value. Moreover, the content of  cTnI in normal serum is very small, and it is significantly increased in AMI, and the increase rate generally exceeds the changes of total CK and CK-MB. Currently, cTnI is mainly used for laboratory AMI diagnosis.
    cTnI protein is a polypeptide chain of 210 amino acids. At present, the main monoclonal monoclonal antibody epitopes used in mainstream kits are concentrated in 24-40, 31-49, 86-90, etc. The pairing methods include 1+1, 1+2 and 2+2.


Product Information

Cat. No. Product name Application-Platform Product Description
HA101-20M cTnI Antibody Detection-Rapid test/FIA Mouse Antibody, a.a.r. 24-40
HA101-13MB cTnI Antibody Detection-Rapid test/FIA Mouse Antibody, a.a.r. 41-49
HA101-10M cTnI Antibody Capture-Rapid test/FIA Mouse Antibody, TroponinC
HA101-11M cTnI Antibody Capture-Rapid test/FIA Mouse Antibody, a.a.r. 83-93
HA101-14M cTnI Antibody Capture-Rapid test/FIA/CLIA Mouse Antibody, specific to troponin Complex
HA101-13H cTnI Antibody Detection-CLIA Humanized Antibody, a.a.r. 41-49
HA101-2M cTnI Antibody Capture-CLIA Mouse Antibody, a.a.r. 24-40
HA101-7M cTnI Antibody Detection-Rapid test/FIA Mouse Antibody, a.a.r. 86-90
HA101-8M cTnI Antibody Detection-Rapid test/FIA Mouse Antibody, a.a.r. 169-178
HP101-1 cTnI Antigen /-Control E.coli, (cTnI-C-I)
HP101-2 cTnI Antigen /-Control E.coli, (cTnI-C-II)